PPARs Signaling and Cancer in the Gastrointestinal System
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چکیده
منابع مشابه
PPARs Signaling and Cancer in the Gastrointestinal System
Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling mo...
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Since the discovery of the peroxisome proliferator-activated receptors (PPARs) in Xenopus frogs as receptors that induce the proliferation of peroxisomes in cells, the study of these factors has received widespread interest. After the characterization of the different isoforms (PPARα, PPARβ/δ, and PPARγ) of these nuclear receptors in the 90s, numerous ligands have been described. Although the r...
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Lipid mediators can trigger physiological responses by activating nuclear hormone receptors, such as the peroxisome proliferator-activated receptors (PPARs). PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism. In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and diffe...
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The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and they decrease therapeutic benefit by increasing the overall treatment time. Emerging evidence ind...
متن کاملPPARs and the cardiovascular system.
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of pharmacologic agents that induce hepatocyte peroxisome proliferation. PPARs also are expressed in cells of the cardiovascular system. PPAR gamma appears to be highly expressed during atherosclerotic lesion formation, suggesting th...
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ژورنال
عنوان ژورنال: PPAR Research
سال: 2012
ISSN: 1687-4757,1687-4765
DOI: 10.1155/2012/560846